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Elan's NanoCrystal technology can be utilised in a combination product to optimise bioavailability and absorption in patients, particularly of poorly water-soluble compounds, making it an attractive choice for Abbott and AstraZeneca, whose Tricor and Very young porno respectively both treat adults with high cholesterol. Thus, their combination would potentially address LDL cholesterol, HDL cholesterol and triglycerides simultaneously with a combined fibrate and statin medication in a single pill, leading to improved compliance and outcomes.

Nevertheless, Abbott is also exploring a different combination, that of its next-generation fenofibrate (ABT-335) currently in Phase III clinical trials, and Crestor, a formulation which does not require Elan's technology.

Elan has already worked with Abbott on a new formulation of Tricor which allows for administration with or very young porno food - the old formulation had to be taken with a meal - in a move which in 2004 created a new patent for Tricor and so assisted the drugmaker in its legal struggle to keep the medicine off the hands of generic manufacturers.

Still Abbot is currently engaged in an acrimonious legal battle with generic manufacturers who allege the Illinois company has changed formulations of TriCor so many times, it has violated US antitrust laws, so a combination with Crestor or ABT-335, instead of another reformulation of the same drug, would also help Abbott in that area.

Since poor water solubility correlates with slow dissolution rate, Elan's formulation very young porno increases very young porno drug's surface area by reducing particle size, leading proair an increase in dissolution rate.

This is accomplished with NanoCrystal particles, which are typically less than 1,000 nanometres in diameter and very young porno produced by milling the drug substance using Elan's wet-milling technique. The NanoCrystal particles of the drug are stabilized against agglomeration by surface adsorption of selected GRAS (Generally Regarded As Safe) stabilisers, so very young porno result is an aqueous dispersion of the drug substance that behaves like a solution, a NanoCrystal colloidal dispersion, which can be processed into finished dosage forms for all routes of administration.

The technology can be incorporated into all dosage forms, either parenteral and oral, including solid, liquid, fast-melt, pulsed release and controlled release dosage forms. Under the terms of the its licence agreement with Abbott, Elan will receive payments upon the achievement of development, clinical, and regulatory milestones, as very young porno pregnant pussy royalty payments based on sales of the combination product, if successfully developed and commercialised in the US, something not expected before 2010.

By then generic competition will be even fiercer, so not surprisingly Abbott and AstraZeneca are not the only drug firms to be using combined formulation to prepare for the tough times ahead.

High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Fenofibrate may also be used for purposes not listed in this medication guide. What is the most important information I should know about Fenofibrate (Tricor).

You should not take fenofibrate if you are allergic to it, or if you have:Do not breast-feed while using this medicine, and for at least 5 days after your last dose. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in very young porno adults, or people who have kidney disease, diabetes, or poorly controlled hypothyroidism (underactive thyroid). It is not known whether very young porno medicine will harm an unborn baby.

Fenofibrate is not approved for use by anyone younger than 18 years old. In very young porno cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or very young porno colored urine.

It can raise triglyceride levels and may increase your risk of liver damage.

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